Dr. Haussam EI., UK, May 2011

"My bone disease before taking Osteoking was bilateral stage 1 AVN; only symptomatic on the right side with constant severe right groin pain.

I started Osteoking in June 2010. However, the decompression took off the pain completely on 30 June 2010. Osteoking has a siginificant added benefit after the operation that enhanced my recovery; allowed me to start my gym exercises 2 weeks after operation very gradually till after 3 months I was off the crutches and running 8 km in 15 minutes on a cycle and at high level of resistance.

My Orthopaedic Consultant was amazed about the speedy recovery which he was not expected until fater a year from the time of operation. In deed, the operation + Osteoking + regular exercises were the key towards regaining my bones healthy again.

I managed to lose weight so far 30 kg. Upon looking at my last MRI, disease process has stopped since Jan 2011 and bone filled up with healthy tissue as well as no secondary osteoarthritis.

I would like to thank all Osteoking team for the constant support and assurance"

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Product Researches

In order to explore its mechanism of the effects, extensive studies and researches have been conducted in foremost level of biochemistry, histomorphology, molecular biology for OsteoKing. The results show that OsteoKing can reduce blood viscosity, improve hemodynamics, reduce internal pressure of bone, improve blood supply, reduce blood fat concentration, reduce the formation of fat embolism and promote the genetic expression of endogenous VEGF(Vascular endothelial growth factor), cbf a1(core binding factor a-1) and BMP-2(Bone morphogenetic proteins-2). It can also strengthen the activity of bone cells and inhibit osteoclast cells.

Observation with optical microscope, transmission electron microscope and scanning electron microscope, the results showed

The general observation:
No-treatment control group: normal femoral head
Model group: modeling cartilage has become thin; the bone trabecula has disordered and appeared oily condition.
OsteoKing group: the thickness of cartilage is normal and fat is little.
The results observed with optical microscope:
No-treatment control group: normal femoral head
Model group: the bone trabecula has disordered and become thinner, sparse. The medullar cavity is full of empty lipid cells.
OsteoKing group: more new bone is formed on the surface of bone trabecula.
The results observed with transmission electron microscope:
Model group: necrosis occurred, the medullar cavity bled, collagen was disturbance
Model group: necrosis occurred, the medullar cavity bled seriously,
Model group: bone tissues have become degenerately necrosis and bleeding
OsteoKing group: new bone trabecula and original bone trabecula
OsteoKing group: more blood capillary appeared
OsteoKing group: more osteoblasts and new bone cells appeared
The results observed with scanning electron microscope:
No-treatment control group: the normal membranous structure on the surface of bone trabecula
Model group: the membranous structure was destroyed
OsteoKing group: the membranous structure was normal and the formation of bone was active


Necrotic bone cells are less in the OsteoKing group, more osteoblasts and osteoclasts, new bone cells and bone matrix are appeared as well as calcium deposit occurs. The results observed with scanning electron microscope indicate that more osteoblasts appeared on the surface of bone trabecula. OsteoKing group has remarkable superiority compares with model group.

Promoting the formation of blood vessel by promoting the genetic expression of endogenous VEGF, effectively improve the activity of osteoblasts and speed the formation of bone cells.

VEGF (Vascular endothelial growth factor) is very closely related to bone repair and plays a very important role in the formation and repair of bone. (Lieberman JR, et al. Instr Course Lect, 2003; 52:337-55. ?Carano RA, et al. Drug Discov Today. 2003, 8(21): 980-989.?Yancopoulos GD,et al. Nature. 2000, 407(6801):242-248. Review.)

Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the expression of endogenous VEGF in the necrotic femoral head and increase the expression volume significantly. Compared with Model group, the difference has statistics significance (p<0.05).

Promoting the development, differentiation, regulation of osteoblasts and bone calcification by boosting the genetic of cbf a1.

cbf a1 (core binding factor ?1) gene is osteogenesis specificity transcription activation factor, It plays a very important role during the development and differentiation of the osteoblast and the bone formation.(Ducy P, et al. Cell, 1997, 89(5):747~754.?Komori T, et al. Cell, 1997, 89(5):755-764.?He J, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2004, 97(2):239-245.)

Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the repair of necrotic bone through promoting the expression of cbf ?1 in the necrotic femoral head and increase the expression volume significantly. Compared with the model group, the difference has statistics significance (p<0.05).

Inducting ossification and stimulating the formation of bone cells by boosting the genetic of BMP-2.

BMP-2 (Bone morphogenetic proteins-2) has very powerful activity in inducting ossification (Wozney JM, et al. Science, 1988, 242(4885): 1528-1534.?Croteau S,et al. Orthopedics, 1999, 22(7):686-695.?Shore EM, et al. Clin Orthop, 1995, (311):199-209.)

Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the repair of necrotic bone through promoting the expression of BMP-2 in the necrotic femoral head and increase the expression volume significantly. Compared with the model group, the difference has statistics significance (p<0.05).

The researches of OsteoKing are performed with the latest modern methods and receive the scientific data, from many angles and aspects to analysis the mechanism of the effects of OsteoKing deeply to the genetic level. Those provide solid scientific data for the end user application. It is the top choice for maintaining the human bone health.

OsteoKing has also been tested and applied on more than ten thousands of clinical cases in many hospitals in China, including the Shanghai Sixth People’s Hospital, Beijing Ji Shui Tang Hospital, Beijing No. 301 Hospital of PLA, Affiliated Hospital of Beijing Medical University, Affiliated Hospital of Guangzhou Sun Yat Sen Medical University, Guangzhou Southern Hospital, Affiliated Hospital of Shandong Traditional Chinese Medical University, Hubei Tong Ji Hospital, Hubei Friendship Hospital, Affiliated Hospital of Zhejiang University, Sichuan Provincial People’s Hospital, Yunnan Provincial People’s Hospital, Affiliated Hospital of Kunming Medical College, the General Hospital of Chengdu Military District, Affiliated Hospital of Harbin Medical University, Affiliated Hospital of the Third Military Medical University. OsteoKing has also been used by the users in the US and Europe and has been highly recommended by the doctors and the patients. It was called "magic herbal product" by the user from UK and "water of life" by the user from Turkey.